Evading inhibitory constraints - destabilizing p110α/p85α interactions

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evading Astrophysical Constraints on Axion-Like Particles

Stellar energy loss arguments lead to strong constraints on the coupling φγγ of a light axion-like particle to two photons. Helioscopes, like CAST, are able to put competitive bounds. The PVLAS experiment has recently observed a rotation of the polarization of a laser propagating in a magnetic field that can be interpreted as the effect of a quite strong φγγ coupling. We present scenarios where...

متن کامل

Destabilizing interactions among [PSI(+)] and [PIN(+)] yeast prion variants.

The yeast Sup35 and Rnq1 proteins can exist in either the noninfectious soluble forms, [psi-] or [pin-], respectively, or the multiple infectious amyloid-like forms called [PSI+] or [PIN+] prion variants (or prion strains). It was previously shown that [PSI+] and [PIN+] prions enhance one another's de novo appearance. Here we show that specific prion variants of [PSI+] and [PIN+] disrupt each o...

متن کامل

Evading Predictors with Creatures

We continue the theory of evasion and prediction which was introduced by Blass and developed by Brendle, Shelah, and Laflamme. We prove that for arbitrary sufficiently different f, g ∈ ωω, it is consistent to have eg < ef , where ef is the evasion number of the space ∏ n<ω f(n). For this we apply a variant of Shelah’s “creature forcing”.

متن کامل

Evading network-level emulation

Recently more and more attention has been paid to the intrusion detection systems (IDS) which don't rely on signature based detection approach. Such solutions try to increase their defense level by using heuristics detection methods like network-level emulation. This technique allows the intrusion detection systems to stop unknown threats, which normally couldn't be stopped by standard signatur...

متن کامل

Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness

Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology. Here, we analyze mice with a hypermorphic Zap70 mutation, W131A, which destabilizes the autoinhibitory conformation of Zap70, rendering the kinase in a semiactive state. W131A mutant mice with wild-...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: FEBS Journal

سال: 2015

ISSN: 1742-464X

DOI: 10.1111/febs.13392